Clemastine fumarate

$105.00

Clemastine fumarate

ntry
D00666                      Drug
Name
Clemastine fumarate (JP18/USP);
Tavist (TN)
Product
  Generic
Formula
C21H26ClNO. C4H4O4
Exact mass
459.1813
Mol weight
459.9624
Structure
Simcomp
Class
Anti-allergic agent
DG01557  Histamine receptor antagonist
DG01482  Histamine receptor H1 antagonist
Metabolizing enzyme inhibitor
DG01645  CYP2D6 inhibitor
Remark
Therapeutic category: 4419
ATC code: D04AA14 R06AA04
Chemical structure group: DG00387
Product (DG00387): D00666<JP/US>
Efficacy
Antiallergic, H1 receptor antagonist
  Disease
Allergic rhinitis [DS:H01360]
Comment
Diphenhydramine derivative
Target
HRH1 [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Structure map
map07212  Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
D04AA Antihistamines for topical use
D04AA14 Clemastine
D00666  Clemastine fumarate (JP18/USP) <JP/US>
R RESPIRATORY SYSTEM
R06 ANTIHISTAMINES FOR SYSTEMIC USE
R06A ANTIHISTAMINES FOR SYSTEMIC USE
R06AA Aminoalkyl ethers
R06AA04 Clemastine
D00666  Clemastine fumarate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Respiratory Tract/Pulmonary Agents
Antihistamines
Histamine (H1) Receptor Antagonists, Sedating
Clemastine
D00666  Clemastine fumarate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
4  Agents affecting cellular function
44  Allergic agents
441  Antihistamines
4419  Others
D00666  Clemastine fumarate (JP18/USP)
Classification of Japanese OTC drugs [BR:br08313]
Agents for nervous and sensory systems
01 Cold remedy (oral use)
D00666  Clemastine fumarate (JP18/USP)
Agents for otolaryngologic use
69 Oral medicine for nasal inflammation
D00666  Clemastine fumarate (JP18/USP)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
Inorganic and organic chemicals
Clemastine
D00666  Clemastine fumarate (JP18/USP)
Drug groups [BR:br08330]
Anti-allergic agent
DG01557  Histamine receptor antagonist
DG01482  Histamine receptor H1 antagonist
DG00387  Clemastine
D00666  Clemastine fumarate
Metabolizing enzyme inhibitor
DG01645  CYP2D6 inhibitor
DG00387  Clemastine
D00666  Clemastine fumarate
Drug classes [BR:br08332]
Anti-allergic agent
DG01482  Histamine receptor H1 antagonist
D00666  Clemastine fumarate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
HRH1
D00666  Clemastine fumarate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00666  Clemastine fumarate
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00666
Rx-to-OTC switch list in the USA [br08315.html]
D00666
Drug groups [BR:br08330]
Anti-allergic agent
DG01557  Histamine receptor antagonist
DG01482  Histamine receptor H1 antagonist
DG00387  Clemastine
Metabolizing enzyme inhibitor
DG01645  CYP2D6 inhibitor
DG00387  Clemastine

Other DBs
CAS: 14976-57-9
PubChem: 7847732
ChEBI: 3739
LigandBox: D00666
NIKKAJI: J240.218A